Circulating levels of gonadotrophins in immature mice treated neonatally with antisera to gonadotrophins

Circulating levels of gonadotrophins in immature mice treated neonatally with antisera to gonadotrophins.

Treatment of immature mice with gonadotrophins. Effects on some enzymic activities of unfractionated ovarian homogenates.

Treatment of immature mice with both follicle-stimulating hormone and human chorionic gonadotrophin in vivo resulted in large increases in the specific activities of ovarian alkaline phosphatase and alkaline nucleotidase. The specific activities of other ovarian enzymes studied were not altered by gonadotrophin treatment. A simultaneous change in the Michaelis constant of ovarian alkaline phosp...

Transgenic animals and gonadotrophins.

A variety of transgenic animal models has been developed to elucidate in vivo the functions of gonadotrophin genes. Some of these have focused on regulatory aspects through expression of gonadotrophin subunit promoter-driven reporter genes. Others have been carried out by overexpression or targeted disruption of specific gonadotrophin subunit genes, or by eliminating pituitary gonadotroph cells...

Serum gonadotrophins in Down's syndrome.

Serum levels of follicle stimulating hormone (FSH) and luteinising hormone (LH) in institutionalised male patients with Down's syndrome (DS) have been found to be significantly higher than in age matched controls from the same institution. This difference is found in patients both under and over 30 years of age with respect to FSH levels, but the increase in LH levels is confined to patients wi...

An immunological cross reaction between monkey gonadotrophin preparations and antisera to human gonadotrophins.

There is still some confusion about the ability of monkey and human gonadotrophins to cross react in immunological systems. McGarry & Beck (1963), using a haemagglutination inhibition technique, found a cross reaction between antisera to human fsh and monkey fsh. They also found a similar cross reaction with lh. Neill, Peckham & Knobil (1967), Bagshawe, Orr & Godden (1968) and Faiman, Ryan, Gre...